1．教育状况

1984.09-1988.06：大连水产学院，学士

2000.09-2003.06：哈尔滨师范大学，硕士研究生

2007.09-2010.06：东北农业大学，博士研究生

2011.09-2012.08：英国阿伯丁大学，苏格兰鱼类免疫研究中心，访问学者

2．工作经历

1988.07-2001.06：哈尔滨农业科学院，高级工程师

2001.07-至今：东北农业大学，动物科学与技术学院水产养殖系，副教授，教授

著作论文

代表性论文

Shuai Gao, Xuefei Liu, Bing Han, Na Wang, Xiaonan Lv, Xueting Guan, Gefeng Xu, Jinshan Huang, Wen Shi*, Min Liu*. Salmonid alphavirus non-structural protein 2 is a key protein that activates the NF-κB signaling pathway to mediate inflammatory responses. Fish & Shellfish Immunology, 2022, 129: 182-190.

Yanru Zhang, Jinhui Sun, Yanxue Shi, Xuefei Liu, Mengmeng Zhang, Baoxing Xu, Jian Song, Zhenguo Song, Xueting Guan, Wen Shi*, Min Liu*. Oncorhynchus mykiss OmTRIM25 activates the interferon-1 pathway and positively regulates the antiviral innate immune response to infectious hematopoietic necrosis virus. Aquaculture, 2022,738435.

Sun J, Zhang M, Zhao D, Yang J, Shi Y, Xu B, Liu X, Guan X, Shi W, Liu M. Immunological Effects of Recombinant Lactobacillus casei Expressing IHNV G Protein and Rainbow Trout (Oncorhynchus mykiss) Chemokine CK6 as an Oral Vaccine. Front Immunol. 2022 Jun 16;13:927443

Li J, Xia D, Zhang M, Zhang Y, Liu X, Sun J, Xu B, Yang J, Wang N, Shi W, Guan X, Liu M. Infectious hematopoietic necrosis virus (IHNV) nucleoprotein amino acid residues affect viral virulence and immunogenicity in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2022 Nov;130:572-581.

Shuai Gao，Na Wang，Jiawei Yang，Jinhui Sun，Yuting Wang，Dong Xia，Jingwen Tian，Yuntong Zhao，Ying Feng，Ying Zhou，Xueting Guan，Wen Shi*，Min Liu*.Development and evaluation of indirect double-antibody sandwich ELISA for rapid detection of Salmonid Alphavirus using Baculoviridae expressed E1 Protein.Aquaculture,2021,737081.

Xiaojing Hua, Ying Zhou, Ying Feng, Kexin Duan, Xuanyu Ren, Jinhui Sun, Shuai Gao, Na Wang, Jiahui Li, Jiawei Yang, Dong Xia, Chunyue Li, Xueting Guan, Shi Wen*, Liu Min*. Oral vaccine against IPNV based on antibiotic-free resistance recombinant Lactobacillus casei expressing CK6-VP2 fusion protein,Aquaculture,2021,736425.

Chen, Y.; Hua, X.; Ren, X.; Duan, K.; Gao, S.; Sun, J.; Feng, Y.; Zhou, Y.; Guan, X.; Li, D.; Wang, N.; Li, J.; Yang, J.; Xia, D.; Shi, W.#; Liu, M.#, Oral immunization with recombinant Lactobacillus casei displayed AHA1-CK6 and VP2 induces protection against infectious pancreatic necrosis in rainbow trout (Oncorhynchus mykiss). Fish & Shellfish Immunology 2020, 100, 18-26.

Yaping Chen; Jiahui Li; Dechuan Li; Xin Guan; Xuanyu Ren; Ying Zhou; Ying Feng; Shuai Gao; Na Wang; Xueting Guan; Wen Shi; Min Liu（*）; The L-domains in M and G proteins of infectious hematopoietic necrosis virus (IHNV) affect viral budding and pathogenicity, Fish & Shellfish Immunology, 2019.10, 95: 171-179

Yaping Chen; Jiahui Li; Ying Zhou; Ying Feng; Xin Guan; Dechuan Li; Xuanyu Ren; Shuai Gao; Jinshan Huang; Xueting Guan; Wen Shi; Min Liu（*）; The role of infectious hematopoietic necrosis virus (IHNV) proteins in recruiting the ESCRT pathway through three ways in the host cells of fish during IHNV budding, Fish & Shellfish Immunology, 2019.09, 92: 833-841

Kexin Duan(#); Xiaojing Hua; Yuting Wang; Yanxue Wang; Yaping Chen; Wen Shi; Lijie Tang; Yijing Li; Min Liu(*);Oral immunization with a recombinant Lactobacillus expressing CK6 fused with VP2 protein against IPNV in rainbow trout (Oncorhynchus mykiss), Fish & Shellfish Immunology, 2018.12, 83: 223-231

Guo Mengting(#); Shi Wen; Wang Yanxue; Wang Yuting; Chen Yaping; Li Dechuan; Ren Xuanyu; Hua Xiaojing; Tang Lijie; Li Yijing; Liu Min(*); Recombinant infectious hematopoietic necrosis virus expressing infectious pancreatic necrosis virus VP2 protein induces immunity against both pathogens , Fish & Shellfish Immunology, 2018.07, 78: 187-194.

刘敏(#) ; 李一经; 赵丽丽; 唐丽杰; 乔薪瑗, 一株重组传染性造血器官坏死病毒rIHNV HLJ-09株及其构建方法和应用(专利 ), 2018.3.30, 中国发明专利.

在研课题

国家自然科学基金面上项目“传染性造血器官坏死病毒G蛋白糖基化位点突变对其逃逸抗原识别及免疫应答的影响”，2022.01- 2025.12，主持

青岛海洋科学与技术试点国家实验室前沿技术自由探索项目“鱼类mRNA疫苗关键技术研究”，2022.10-2024.10，主持

国家“十三五”科技部国家重点研发项目“动物疫病生物防治性制剂研制与产业化”子课题，，2017-2020，主持

国家自然基金面上项目“传染性造血器官坏死病毒感染性克隆嵌合病毒的构建及其免疫原性研究”，2017-2020：主持